Thus, this study was conducted to translate and validate it in the Hindi speaking population. However, its Hindi version is not available. Cambridge-Hopkins diagnostic questionnaire for RLS (CHRLSq) is a good diagnostic tool and can be used in the epidemiological studies. Restless legs syndrome also known as Willis-Ekbom's Disease ( RLS/WED) is a common illness. Gupta, Ravi Allan, Richard P Pundeer, Ashwini Das, Sourav Dhyani, Mohan Goel, Deepak Hindi translation and validation of Cambridge-Hopkins Diagnostic Questionnaire for RLS (CHRLSq). These studies should include genetic, clinical and polysomnographic variables, as well as hormonal measures and variables assessing iron metabolism. Therefore, further, preferably longitudinal studies are needed to unravel the factors causing RLS in women. But, menopause does not lower the incidence of RLS nor does hormone replacement therapy lead to an increase, suggesting a quite complex uncertain role of hormones in the pathophysiology of RLS. Some evidence suggests that dysfunction in iron metabolism and high estrogen levels might contribute to RLS during pregnancy.

Parity increases the risk of RLS later in life suggesting that pregnancy is a specific behavioral risk factor for developing RLS. RLS will generally become worse or might appear for the first time during pregnancy. The present review focuses on RLS in females from the perspectives of both epidemiology and pathophysiology. Since then numerous studies have reported that women are affected by RLS about twice as often as males for mild as well as moderate to severe RLS. He, however, reported this gender difference mainly for those with more severe symptoms. Restless legs syndrome ( RLS) as one cause of disturbed sleep was observed to be somewhat more common among women than men in Ekbom's 1945 seminal series of clinical cases with the disease.

Disturbed sleep, in particular, is much more prevalent in females than males. Sleep is an essential human behavior that shows prominent gender differences. Manconi, Mauro Ulfberg, Jan Berger, Klaus Ghorayeb, Imad WesstrÃ¶m, Jan Fulda, Stephany Allen, Richard P PollmÃ¤cher, Thomas Report of the ' RLS and woman' workshop endorsed by the European RLS Study Group.

When gender matters: restless legs syndrome.

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